The global firm will give the funds to Feeding America, formerly known as America's Second Harvest, to help purchase fresh and non-perishable potatoes for its food banks to distribute to families in need.
The 30-second commercial, a collaboration between Syngenta, the National Potato Council and the United States Potato Board, highlights some of the lesser known nutritional facts about potatoes.
Mary DeMers, horticulture communication manager at Syngenta, said: "This is a wonderful opportunity for Syngenta to educate people on the health benefits of the potato while also working with an organisation that, like Syngenta, does its part to feed the world.
"We believe reaching the consumer about the health benefits of potatoes is very important.
"Our donation to Feeding America is also important given the economic situation as the holiday season approaches. We're looking forward to touching the lives of many Americans through this effort, especially since potatoes are such a large part of the Thanksgiving holiday tradition."